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Serotonin (5-HT) appears to play a modulatory role in the behavioral effects of cocaine, although the impact of 5-HT 2C receptors in this control has not been fully established. The aim of the present study was to establish whether acute pretreatment with the selective 5-HT 2C/2B antagonist SB 206553 (1, 2, and 4 mg/kg IP) altered hyperactivity induced by cocaine...
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