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Rhinovirus (RV) infections are linked to the development and exacerbation of allergic diseases including allergic asthma. IgE, another contributor to atopic disease pathogenesis, has been shown to regulate DC antiviral functions and influence T cell priming by monocytes. We previously demonstrated that IgE‐mediated stimulation of monocytes alters multiple cellular functions including cytokine secretion,...
BackgroundRhinovirus and IgE act in concert to promote asthma exacerbations. While basophils are the principal cell type in the blood that is activated by IgE, their role in virus‐induced asthma episodes remains elusive.
ObjectiveTo monitor IgE responsiveness in circulating basophils of rhinovirus‐infected atopic asthmatics during acute infection and convalescence.
MethodsThe capacity for basophils...
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