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Regulation of gene expression has been shown to involve not only binding of transcription factor in target gene promoters but also characterization of histone around which DNA is wrapped around. Some histone modification, for example di-methylated histone H3 at lysine 4 (H3K4me2), has been shown to be associated with gene activation. However, no clear pattern has been shown to predict human promoters...
A system to control the differentiation of human mesenchymal stem cells (hMSCs) using RNAi methods is being investigated. Through this delivery system, we aim to induce the differentiation of stem cells for a variety of regenerative medicine applications. In these preliminary studies, we have characterized both the cytotoxicity and uptake of our polymeric system relative to commercial siRNA delivery...
Gene expression models play a key role to understand the mechanisms of gene regulation whose aspects are grade and switch-like responses. Though many stochastic approaches attempt to explain the gene expression mechanisms, the Gillespie algorithm which is commonly used to simulate the stochastic models hardly explain the switch-like behaviors of gene responses. In this study, we propose a stochastic...
In this paper, we provide an in silico input-output characterization of a three-terminal transcriptional device employing polymerase per second (PoPS) as input and output. The device is assembled from well-characterized parts of the bacteriophage ?? switch transcriptional circuit. We draw the analogy between voltage and protein concentration and between current and PoPS to demonstrate that the characteristics...
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