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The goal of this study is to design a scaffold, utilizing topographical features on the nanometer scale, to determine the relationship between those features and cellular orientation during in vitro cell culture. Ultimately the goal of this study is to control the structure of engineered tissue which can be accomplished by directing cellular orientation during growth. The control of tissue structure...
The protein adsorption is a crucial but complex phenomenon in many applications, like biosensors, biomaterials. The amount, orientation and biological activity of adsorbed proteins are heavily dependent upon the structure of protein, like widely-applied Bovine Serum Albumin (BSA), and the properties of the substrate. At some extent, to explore the physicochemical properties and dynamics interaction...
This paper proposes an innovative microfluidic device for hyaluronic acid (HA) extraction and electrochemical detection utilizing PMMA based microchip that integrated with gold nanoelectrode ensemble (GNEE). Gold nanoelectrode ensemble is fabricated using electroless deposition in a thin polycarbonate (PC) film and then directly bonded onto the PMMA substrate for high performance electrochemical detection...
Protein interactions have great significance in biomedical and bioengineering research. It is a challenge to form an ideal protein surface. Self assembled monolayers (SAMs) is a rather new chemical method which is easily handled to fabricate a well defined protein surface. In this work, we performed alkanethiol monolayers with carboxyl end groups, and mixed alkanethiols monolayers with carboxyl and...
The study of protein dynamics has expanded considerably in the last ten years, in large part because of the wider availability of parallel supercomputers. But the growth in computing power is not sufficient: new numerical approaches must also be developed that allow for a more efficient sampling of configuration space. In this presentation, I will present some recent progress on the methodological...
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