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Finding gene clusters that can be shared between drugs and diseases plays an important role in drug discovery. Targeting disease causing genes directly in drug development can increase the chance of drug approval through the clinical phase. This paper introduces a new co-clustering approach on the tripartite graph of genes, drugs, and diseases. As a result of co-clustering, gene modules and their...
Diabetes Mellitus Type 2 is one of the common diseases and found worldwide. The cause of this abnormality is due to lack of insulin production. Glucagon like peptide-1 (GLP-1), product of the glucagon gene is one of the prime components which stimulates the β cell proliferation and inhibits β cell death. DiPeptidyl Peptidase IV (DPP IV) acts as protease degrading incretins which stimulates the secretion...
The purpose of this article was to observe interaction between drug and cancer cell with fluorescence probes and molecular imaging technology. In order to study the effect of cell growth and apoptosis morphology of Human gastric adenocarcinoma SGC-7901 induced by n-butanol extract from Capparis spionosa L. (CSBE), laser scanning microscopy was employed to observe apoptosis imaging. In addition, the...
The purpose of this article was to observe interaction between drug and cancer cell with fluorescence probes and molecular imaging technology. In order to study the effect of cell growth and apoptosis morphology of Human gastric adenocarcinoma SGC-7901 induced by n-butanol extract from Capparis spionosa L. (CSBE), laser scanning microscopy was employed to observe apoptosis imaging. In addition, the...
Burkitt's lymphoma (BL) is a highly aggressive malignant tumor with high morbidity rate in children. Patients have different responses to the same therapy due to the molecular heterogeneity. Detailed observation of the surface structure of BL cells to locate the specific receptors (CD20) on the cell surface and measure the binding force between the CD20s and their cognate ligands (Rituximab) may give...
Nanoparticles with various formations were produced based on ionic gelation process between chitosan and tripolyphosphate (TPP) by using bovine serum albumin (BSA) as a model drug. Their average diameter was 300-700 nm with the examination of laser granularity analyzer. The morphologies were examined with optical microscope and TEM. FTIR was used to study the structure characterization between chitosan...
We evaluated three non-invasive method, thermography, laser Doppler imaging and near infrared multi-spectral imaging to quantitatively assess parameters of vascularity in Kaposi's sarcoma. The KS lesion generally has increased temperature, blood velocity and blood deoxy-hemoglobin. There is a strong correlation between temperature and blood velocity (R= 81, p<0.001). After treatment with experimental...
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