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We have evaluated the role of prostaglandin E 2 (PGE 2 ) in the synthesis of nitric oxide (NO) by the activation of the inducible form of nitric oxide synthase (NOS) in the murine macrophage cell line, J774, stimulated with different doses of lipopolysaccharide (LPS). The stimulation of the J774 line with suboptimal doses of LPS (0.1 μg/mL) caused a production of endogenous PGE ...
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