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Fully atomistic molecular dynamics (MD) simulations and NMR spectroscopy were employed to get insights about the molecular details of drug-dendrimer supramolecular association phenomena, using piroxicam (PRX) and the third generation poly(amido amine) (PAMAM-G3) dendrimer as model systems. Theoretical results concerning the complex stoichiometry suggest that PRX forms drug-dendrimer complexes of the...
The complexation of piroxicam and 2-hydroxypropyl-β-cyclodextrin by means of supercritical CO 2 has been investigated. The experiments were carried out by varying the temperature, pressure and contact time and introducing two different auxiliary agents: polyvinyl pyrrolidone or l-lysine.Cyclodextrins, which are widely used to solubilize a large variety of poorly soluble drugs, are often used...
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