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Recent studies have suggested that the proliferation of malignant gliomas may result from activation of protein kinase C (PKC)-mediated pathways; conversely, inhibitionof PKC may provide a strategy for blocking tumor growth.In the current studies, we examined the effect of a novelPKC inhibitor, calphostin C, which is a selective, highlypotent, photo-activatable inhibitor of the PKC regulatorydomain,...
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