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Since its discovery as the principal mediator of humoral hypercalcemia of malignancy, parathyroid hormone-related protein (PTHrP) has emerged as a key player in skeletal complications associated with solid tumor metastasis to bone. In addition to functioning as an endocrine factor, this pleiotropic peptide mediates its actions locally on tumor and stromal cells in paracrine, autocrine, and intracrine...
The extracellular calcium-sensing receptor (CaR) is a versatile ‘sensor’ for di- and polycationic molecules in the body. CaR plays a key role in the defense against hypercalcemia by “sensing” extracellular calcium levels in the parathyroid and kidney, the key organs maintaining systemic calcium homeostasis. Although mutation of CaR gene has so far not been associated with any malignancy, aberrant...
Parathyroid hormone-related protein (PTHrP) is produced by a wide range of neoplastic and normal cells, including keratinocytes where it may regulate growth and differentiation. Transforming growth factor-β (TGF-β) is a growth factor produced by many cells, including keratinocytes where it regulates epidermal homeostasis. TGF-β has been reported to be cosecreted with PTHrP in some neoplasms and to...
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