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The functions of proteins are closely related to their subcellular locations. In the post-proteomics era, the amount of gene and protein data grows exponentially, which necessitates the prediction of subcellular localization by computational means. This paper proposes mitigating the computation burden of alignment-based approaches to subcellular localization prediction by using the information provided...
Ribonuclease 3 (RNase3) is a member of the human RNaseA superfamily. It is led by a 27-residue signal peptide and secreted into body fluid to eliminate the infection of microbial pathogens in innate immune systems. The signal peptide of RNase3 (RNase3sp) not only directs protein secretion via endoplasmic reticulum (ER) and Golgi apparatus, but also its N-terminal 17 amino acid residues (RNase3sp1-17)...
Mimotopes are peptides mimicking an epitope. They can readily be selected out from phage-displayed random peptides libraries and have been widely used, especially in epitope mapping. There are now several computational tools available for the mimotope based epitope mapping. Most of these tools implicitly take peptides acquired through phage display as mimotopes in an extended conformation and map...
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