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Vaccinia virus (VACV) is the vaccine for smallpox and a widely used vaccine vector for infectious diseases and cancers. The majority of the antibodies elicited by live VACV vaccination respond to virion structural proteins, including many integral membrane proteins on the intracellular mature virion (MV). Here, we showed that antibody response to an exogenous antigen delivered by VACV was greatly...
The F1 antigen of Yersinia pestis has been identified as one of the protective antigens. The present study aims to generate anti-F1 antibodies in mice of different genetic background and to compare antibody profile, isotype distribution and avidity measurement in sera to observe the pattern of immune response as a strategy to develop F1-based immunogen for plague. The study indicated that, although...
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