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This study was designed to determine the minimum effective concentration of paraquat that modulated the expression of PKD-related genes in Drosophila. We first studied the viability of Drosophila and then tested the expression of the PKD-related genes—Parkin, UCH, and tau—in various concentrations of paraquat in the water sucked by Drosophila. The lowest effective concentration of paraquat was approximately...
Possible cell death mechanisms for pars compacta nigro-striatal dopamine neurons in Parkinson’s disease include oxidative stress, inflammatory processes, nitric oxide, iron accumulation, glutamate toxicity and diminished neurotrophic factor responses. There is a notion that Parkinson’s disease is not a single disorder but a syndrome that can be initiated by several factors. Because of limitations...
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