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Proteasomes are the main non-lysosomal, multicatalytic proteinase complexes involved in the degradation of most intracellular proteins and in numerous cell processes. Studies from isolated cell models indicate that agents that induce oxidative stress may also damage proteasomes. Similarly, continuous oxidative stress during cell aging may impair proteasome activity. In ischemia-reperfusion models...
Clone 9 liver cells incubated under aerobic conditions with the proteasome inhibitors lactacystin, clastro lactacystin β-lactone, and tri-leucine vinyl sulfone, in the absence of an obvious oxidative challenge, underwent oxidative protein modifications, such as loss of solubility, formation of aggregates (predominantly by disulfide bridges), and increased carbonyl formation, similar to those seen...
Tight linkage between aging and oxidative stress is indicated by the observations that reactive oxygen species generated under various conditions of oxidative stress are able to oxidize nucleic acids, proteins, and lipids and that aging is associated with the accumulation of oxidized forms of cellular constituents, and also by the fact that there is an inverse relationship between the maximum life...
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