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Nuove Reti Sanitarie is a telemonitoring service for patients with chronic heart failure (CHF) successfully implemented in Lombardia Region, Italy, over the period 2006-2008. In particular, the purpose of this paper is to describe the implementation process and the assessment results of this telemedicine service. 609 patients (70 ?? 12 years) affected by CHF (91.6% and 8.4% in NYHA III and IV, respectively)...
In this paper we explore the applications of artificial neural networks in the field of heart surgery, more specifically in the prognostic evaluation of post-surgery complications, such as death, reintubation, prolonged mechanical ventilation and the need for extracorporeal circulation in patients who underwent coronary artery bypass graft surgery. Predictive variables were limited to information...
Regulatory actions through 2007-2008 demonstrate FDA's response to multiple reports of sudden death and severe cardiopulmonary reactions temporally related to the administration of Ultrasound Contrast Agents (UCA). Certain animal data showed similar adverse effects at a clinically relevant dose. The products labels were changed to include the boxed warning encouraging healthcare providers to assess...
Cardiomyocyte death is a critical risk factor in a variety of cardiovascular diseases. At the level of individual cardiomyocyte, cell adhesion alters at the early phase of ongoing death. In the previous study, we developed the impedance-sensing technique for real-time monitoring cardiomyocyte adhesion. In this work, we demonstrated the application of our impedance-sensing technique in regulating cell...
The commonest cause of sudden cardiac death is anomalous origin of coronary arteries (AOCA). Conventional coronary angiography is the gold standard for the diagnosis of AOCA. However, this technique is limited by its invasive. Multi-detector computed tomography electrocardiogram is increasingly important tool in the identification and assessment of cardiac-related disease processes, including those...
More than 37 years have passed since Charles F. Dalziel published his last of four seminal papers on ventricular fibrillation (v-f ). His empirical formula for the current necessary to produce v-f in man has been recognized by scientists and engineers as forming the basis for an analytical understanding of this major cause of death from electrical shock. In this article, the additional electrical...
In an attempt to study the importance of T-wave feature selection for T-wave alternans (TWA) analysis, we compared the alternans in two vectorcardiographic variables: maximal T-loop vector (MaxT) and the T-loop vector integral (Ti). We analyzed TWA in the 72 standard 12-lead ECGs comprised in the Physionet TWA challenge database with our research ECG/VCG processing program LEADS. We computed TWA by...
This paper proposes electrocardiographic mismatch (ECGM) to quantify differences in the long-term ECG signals for two patients. ECGM compares the symbolic distributions of ECG signals and measures how different patients are electrocardiographically. Using ECGM, we propose a hierarchical clustering scheme that can identify patients in a population with anomalous ECG characteristics. When applied to...
T-wave alternans (TWA) is characterized by a pattern of beat-to-beat alternations in the amplitude of the T-wave of the electrocardiogram (ECG). However, TWA is usually very small and hard to detect or measure. Our aim was to develop and compare three automated TWA measurement algorithms. 100 ECG recordings provided by the 2008 PhysioNet/Computers in Cardiology Challenge were analysed. After ECG pre-processing`moving...
The 9th annual PhysioNet/Computers in Cardiology challenge invited participants to measure T-wave alternans (TWA) in a set of 100 two-minute electrocardiograms that included subjects with a variety of risk factors for sudden cardiac death (including ventricular tachyarrhythmias, transient myocardial ischemia, and acute myocardial infarctions), healthy controls, and synthetic ECGs with calibrated amounts...
The influence of T-wave alternans (TWA) on vectocardiographic parameters has been presented. Alternations in the length and the angle of T-wave loop vector have been found between odd and even beats in electrocardiograms with detectable T-wave alternans. The study shows the significance of changes of T-wave loop vector length and angle in the process of shaping Twave alternans signal. The aim of the...
For the detection and analysis of T-wave alternans (TWA) is offered use the integral method based on the Walsh functions spectral amplitudes calculation. Spectral transformation in basis of Walsh functions was produced in time-domain window with 132 ms duration, located symmetrically to energy center of the ST/T-wave in each heartbeat. Values of spectral amplitudes are possible to consider as qualitative...
Chronic heart failure (CHF) is a major and growing public health concern (~23 million people worldwide) with five-year survival rates of 25% in men and 38% in women. Objective of this study was to investigate whether linear and nonlinear heart rate variability (HRV) indices enhance risk prediction in patients with CHF. To discriminate between low risk (stable condition, N = 459) and high risk (cardiac...
Patients with idopathic dilated cardimyopathy (IDC) and reduced left ventricular function have a limited prognosis. Aim of this study was the evaluation of parameters of cardiac magnetic resonance imaging (CMRI) and ECG for prognosis. 149 patients with IDC were studied by CMRI for hemodynamic and late enhancement (LE) analysis and followed for a mean of 986 plusmn 588 days. QRS and QTc intervals were...
We computed normal limits of the spatial QRS-T angle (SA) and the spatial ventricular gradient (SVG) in 660 normal resting ECGs (449 female / 211 male) recorded in healthy subjects aged 18-29 years. Values for males and females were compared, and normal limits for males from this study were compared to the normal limits for males, published previously in 1967. In females, the SA was sharper (females:...
Idiopathic short QT (SQT) syndrome is a recently identified, genetically heterogeneous condition characterized by abbreviated QT intervals and an increased susceptibility to arrhythmia and sudden death. In this computer simulation study, we identify the mechanisms by which cellular electrophysiological changes in the SQT syndrome associated with V307L KvLQT1 (KCNQ1) gene mutation (the gene coding...
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