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Neurons have been classically considered insulin-insensitive cells. In this in vitro study, the effect of insulin on neuronal glucose uptake was studied by assaying glucose uptake, translocation of glucose transporter isoform GLUT3, and fusion of GLUT3 vesicles with the plasma membrane. Insulin (50 nM) promoted translocation of GLUT3 to the plasma membrane. However, insulin neither promoted fusion...
Neurons exposed to zinc exhibit activation of poly(ADP-ribose) polymerase-1 (PARP-1), an enzyme that normally participates in DNA repair but promotes cell death when extensively activated. Endogenous, vesicular zinc in brain is released to the extracellular space under conditions causing neuronal depolarization. Here, we used a rat model of insulin-induced hypoglycemia to assess the role of zinc release...
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