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The osteoinductive capacity of biological noncellular material has been widely recognized. Studies using bone morphogenetic proteins and acellular bone matrix demonstrate that host mesenchymal cells can be readily transformed into osteoprogenitor cells. The current study sought to determine whether another biological noncellular material, human spinal cord matrix, could induce transformation of host...
Myeloid/lymphoid or mixed-lineage leukemia; translocated to chromosome 11 or ALL1 fused from chromosome 1q (MLLT11/AF1q) is a highly conserved 90 amino acid protein that functions in hematopoietic differentiation. Its translocation to the Trithorax locus has been implicated in malignancies of the hematopoietic system. However, the spatio-temporal profile of MLLT11 expression during embryonic development...
This study evaluated the neural differentiation of human neural stem /progenitor cells (hNPCs) on electrospun fibrous piezoelectric polyvinylidene fluoride-trifluoroethylene (PVDF-TrFE) scaffolds. We hypothesize aligned fibrous piezoelectric scaffold would provide both physical cues (via contact guidance) and local electrical activity to promote neuronal differentiation and neurite extension. hNPCs...
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