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Gene therapy has been considered to be a powerful approach for the prevention and/or treatment of a variety of diseases from genetic disorders, infections, to cancer. The success of gene therapy in the clinic is largely limited currently, mainly due to the lack of safe and efficient delivery vectors. Despite the high transfection efficiency, viral vectors encounter the vital toxicity issues and production...
The main aim of the present study was to compare mucoadhesion and cellular uptake efficiency of chitosan (CS) and chitosan oligosaccharide (COS) surface-modified polymer nanoparticles (NPs) for mucosal delivery of proteins. We have developed poly (d, l-lactide-co-glycolide) (PLGA) NPs, surface-modified COS-PLGA NPs and CS-PLGA NPs, by using double emulsion solvent evaporation method, for encapsulating...
Chitosan/tripolyphosphate/chondroitin sulfate (Chi/TPP/CS) nanoparticles were prepared by an ionic gelation method to obtain a controlled release of proteins. Using Nel‐like molecule‐1 (Nell‐1), a novel osteogenic protein, as a model protein, it was demonstrated that adjusting the composition of the particles modulated the protein association and release kinetics of incorporated proteins. Increasing...
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