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To assess a walking model utilizing a set of standardized treadmill walks to measure acute analgesic response in osteoarthritis (OA) of the knee.Randomized, double-blind, placebo-controlled, multiple dose, three-period crossover study. Patients ≥45 years of age (N=22) with symptomatic knee OA were randomized to naproxen 500mg bid, tramadol/acetaminophen 37.5mg/325mg in forced titration, or placebo...
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