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Cardiac function is reduced after acute myocardial infarction due to myocardial injury and to changes in the viable non-ischemic myocardium, a process known as cardiac remodeling. Current treatment of patients with acute myocardial infarction (AMI) reduces infarct size, preserves left ventricular function, and improves survival. However, it does not prevent remodeling which leads to heart failure...
Myocardial infarction (MI) is a major source of morbidity and mortality worldwide, with over 7 million people suffering infarctions each year. Heart muscle damaged during MI is replaced by a collagenous scar over a period of several weeks, and the mechanical properties of that scar tissue are a key determinant of serious post-MI complications such as infarct rupture, depression of heart function,...
An improvement of biventricular pacing (BVP) could be possible by detecting the patient specific optimal pacemaker parameters. Body surface potential map (BSPM) is used to obtain the electrophysiology and pathology of an individual patient non-invasively. The clinical measurements of BSPM are used to parameterize the computer model of the heart to represent the individual pathology. The computer model...
The role of the 3D infarct structure in arrhythmia generation and maintenance in hearts with myocardial infarction cannot be fully elucidated through experimental techniques alone. Our aim was to develop methodology to construct a high resolution computational model of the infarcted canine heart using magnetic resonance (MRI) and diffusion tensor images (DTI) and then to use the resulting model to...
Hypothesis/Objective: The aim of this study is to characterize the location and extent of moderate to large, relatively compact infarcts using ECG evidence. Method: In this paper, we proposed a method on the basis of vectorcardiography which assumes that heart vector is proportional to relevant active depolarization area(s). To examine our ideas, we used the normal VCG which includes the information...
A model-based approach to noninvasively determine the location and size of the infarction scar is proposed, that in addition helps to estimate the risk of arrhythmias. The approach is based on the optimization of an electrophysiological heart model with an introduced infarction scar to fit the multichannel ECG measured on the surface of the patient's thorax. This model delivers the distributions of...
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