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Neuroblastoma Therapy
In article number 2201671, Zhen Liu and co‐workers construct polysialic acid‐targeting nano‐missiles via a molecular imprinting strategy using oligosialic acid containing 4‐7 units digested from polySia as the template. Effective targeted photothermal therapy of neuroblastoma is achieved using nano‐missiles loaded with the near‐infrared fluorescent reactive dye indocyanine green...
Exploring new targets and developing novel targeted therapies are urgently needed for neuroblastoma therapy. Polysialic acid (polySia), a linear homopolymer of sialic acid units that correlates well with tumor progression and poor prognosis, has emerged as a potential target for neuroblastoma. However, the lack of polySia‐specific binding reagents has severely limited the development of polySia‐targeting...
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