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In clinical applications, peripheral nerve stimulation is usually delivered by means of commercial devices. The main use of these devices is Transcranial Magnetic Stimulation, in fact the coils are designed for a good stimulation of brain. The purpose of this paper is to design a new coil for magnetic stimulation of nerves, which allows a deep stimulation but, at the same time, characterized by high...
The effect of high frequency repetitive transcranial magnetic stimulation (rTMS) with a subthreshold intensity on hemodynamic response in brain cortices (both motor and prefrontal cortices) was investigated using the functional near infrared spectroscopy (fNIRS) technique. FNIRS signals of the motor and prefrontal cortices were acquired in healthy volunteers (n=7) at rest and during rTMS intervention...
We have developed a new type of magnetic field generation and stimulation device based on the principle of electromagnetic induction for the needs of the research on biological signals base on some magnetic field stimulation in our laboratory,. The design can output a single or continuous low frequency pulse magnetic signals, the maximum magnetic induction intensity in the magnetic stimulation coil...
Transcranial magnetic stimulation (TMS) is a medical treatment aimed at modulating the activity of cerebral targets, through pulses of electric field generated inside the brain.
Transcranial Magnetic Stimulation (TMS) is a non-invasive, safe and promising therapy for neurological conditions which utilizes transient magnetic fields for inducing electric field in the brain.
The uncertainty quantification problem in Transcranial Magnetic Stimulation is solved by means of a realistic head model and considering the statistical correlation between grey matter and white matter electrical conductivities. The fast model order reduction approach, introduced by the authors, is extended here to the general case of correlated random parameters. Numerical results prove that correlations...
Schizophrenia is a psychotic disorder. One percent of the population is suffer from schizophrenia. The patients cannot differentiate real situation from imaginary. Auditory hallucination is the most common symptom of schizophrenia. It causes hyper-activity at auditory area of the brain. The schizophrenia mental disorder is chronic, but treatable. In this paper, we proposed the system with local low...
Human brain is a very complex organ and may suffer from various diseases and disorders. Therefore, techniques are required to diagnose the disorders and provide necessary treatment. Electrical or magnetic deep brain stimulation has been successfully used for both these purposes. This research develops a type of therapy that uses stimulation to treat neurological disorders, diseases of the central...
Previous studies showed that the electromagnetic stimulation could effectively biology tissue. However, electrical stimulation effects would be decayed greatly in biological tissues. In this paper, based on the magnetic stimulation system, the principle of magnetic stimulation devices for K-ras driven lung cancer is analyzed. The FEM simulation and biological experiments are conducted. The cell experiments...
Stroke affects more than 16 M people worldwide and emergency treatments are available for less than 5% of the patients. Magnetic stimulation of the facial nerve has been tested in pre-clinical studies as a new, non-invasive emergency treatment of ischemic stroke that acts by increasing cerebral blood flow (CBF). The objective of this study in healthy human subjects is to help understand the safety,...
Magnetic stimulation of the facial nerve has been shown to dilate cerebral arteries and increase cerebral blood flow. We began proof-of-concept testing of a magnetic stimulator as an early clinical treatment for stroke in 2010. In 2014 we founded Nervive, Inc., to develop a commercial clinical device we called the VitalFlow stimulator, which is currently undergoing clinical trials under FDA oversight...
In this work we present a novel platform of micro-inductors designed to perform magnetic stimulation in neural cells and neural slices in vitro. The fabrication along with design considerations are presented. The fabricated platform consists of a 6×6 array of micro-inductors and achieves spatial magnetic flux profiles with a resolution of 100μm. The capability of the platform to perform magnetic stimulation...
Transcranial magnetic stimulation is a neurostimulation technique which has the potential to serve as a unique research tool for investigating a wide variety of fields in cognitive neuroscience. TMS has been approved by the FDA to serve as a treatment to depression and has also been used to evaluate its effects among several conditions such as Alzheimer, Parkinson disease, chronic pain and stroke...
We studied the correlation between corticospinal signaling and neuromuscular properties in children with Cerebral Palsy (CP). Corticospinal signaling was evaluated using Transcranial Magnetic Stimulation (TMS). Neuromuscular properties were quantified using Hoffmann reflex (H-reflex), sonoelastography, clinical measurements, and isokinetic measures. In particular, we determined the relationship between...
This paper presents the cellular proliferation effects of the exposure to extremely low frequency electromagnetic fields (ELF-EMF) on in-vitro cellular cultures HeLa and CHO. Through the magnetic stimulation system (MSS) the cells were exposed to magnetic fields with sinusoidal waveform at 50 Hz; initially for 40 minutes at intensities of 0.4 mT, 1.4 mT, 2.13 mT, 2.49 mT and 2.53 mT in parallel and...
Peripheral stimulation is known to influence the state of cortical excitability. The purpose of this study is to investigate whether peripheral magnetic stimulation has similar effects on cortical excitability to transcranial magnetic stimulation (TMS). A magnetic stimulator with a flat figure-of-eight coil was used for both TMS, and peripheral magnetic stimulation applied to the bilateral forearms...
Prefrontal cortex (PFC) plays an important role in the emotional processing as well as in the functional brain network. Hyperactivity in the right dorsolateral prefrontal cortex (DLPFC) would be found in anxious participants. However, it is still unclear what the role of PFC played in a resting functional network. Continuous theta burst transcranial magnetic stimulation (cTBS) is an effective tool...
Effective and secure arousal method for car drivers preventing drowsy driving has been developed using physiological magnetic stimulation on driver's spine position. The magnetic stimulation method does not accompanied with so-called sleep rebound phenomenon that has been generally indicated for arousal methods using sensory stimulation. Existence of the sleep rebound phenomenon for sensory stimulations...
Acupuncture is effective to treat various diseases. However, the underlying regulation mechanisms of acupuncture remain unclear. In this paper, repeated-pulse magnetic stimulation was used to stimulate the left Hegu (LI4) point of healthy people. EEG signals were recorded before and during magnetic stimulation. Based on the theory of complex network analysis, functional networks under multi thresholds...
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