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Drug delivery system (DDS) is the process of administering a drug-loaded composite to achieve a therapeutic effect in vitro or in vivo. In this paper, we present the fabrication of imiquimod-poly(ε-caprolactone) (PCL) fibre meshes for the melanoma therapy application. The fabrication was based on the electrospinning technique and NIH-3T3 fibroblast cells were cultured on electrospun fibre meshes to...
In this work, N, O-carboxymethyl chitosan (CMCS) samples from virgin chitosan (CS) were synthesised and CMCS/polyethylene oxide (PEO) (50/50) blend nanofibrous samples were successfully electrospun from their aqueous solution. The electrospinning conditions to achieve smooth and fine diameter nanofibrous mats were optimised via D-optimal design approach. Afterwards, vitamin C and phenytoin sodium...
Biodegradable polymer polycaprolactone (PCL; Mw~100,000) fiber mats containing shikonin from the plant Lithospermumerythrorhizon, widely known for its wound healing, anti-tumor, antioxidant, and anti-inflammatory properties, were prepared via electrospinning method. Incorporation of shikonin in the neat PCL solution did not affect the morphology of the resulting fibers, as both the neat and the shikonin-loaded...
In the present study, Eudragit L100 was successfully spun into ultrafine fibers using electrospinning process. The electrospinnability of Eudragit L100 in DMAc, ethanol, methanol, and the mixed solvents of DMAc and methanol with different ratios were examined. The morphologies of the as-spun Eudragit L100 fiber mats were observed using SEM. The results demonstrated that Eudragit L100 was able to be...
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