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Determination of the intrinsic efficacy of ligands at the 5-HT 1A receptor is important for selecting drug candidates, e.g. in the case of schizophrenia where partial agonism is a favorable property shared by different atypical antipsychotics.Using seven ligands with different intrinsic efficacies and rat hippocampus synaptosomes, we compared critically three “functional” binding assays based...
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