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Background and objectiveInterleukin (IL)‐25 has been implicated in the pathogenesis of human asthma by inducing a Th2 cytokine response, but its possible role in the development of airway remodelling is less clear.
MethodsWe developed a murine surrogate of chronic airway inflammation induced by intranasal application of IL‐25 alone. Comparison was with the ‘classical’ surrogate of ovalbumin (OVA)...
BackgroundInterleukin‐25 has been implicated in the pathogenesis of asthma from studies on human asthmatics and in murine asthma models.
ObjectivesIn this study, we hypothesized that chronic exposure of the airways to IL‐25 alone is able to induce pathogenic changes observed in animal models of asthma.
MethodsWe performed a detailed comparison of the dynamics of development of cellular infiltration,...
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