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ScopeWe have previously demonstrated that oleuropein (OL) and hydroxytyrosol (HT) reduce 17β‐estradiol‐mediated proliferation in MCF‐7 breast cancer (BC) cells without affecting the classical genomic action of estrogen receptor (ER), but activating instead the ERK1/2 pathway. Here, we hypothesized that this inhibition could be mediated by a G‐protein‐coupled receptor named GPER/GPR30. Using the ER‐negative...
Olive oil intake has been shown to induce significant levels of apoptosis in various cancer cells. These anti-cancer properties are thought to be mediated by phenolic compounds present in olive. These beneficial health effects of olive have been attributed, at least in part, to the presence of oleuropein and hydroxytyrosol. In this study, oleuropein and hydroxytyrosol, major phenolic compound of olive...
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