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The pharmacological profile of a new, safe, and effective hydrogen sulfide (H 2 S)-releasing derivative of aspirin (ACS14) is described. We report the synthesis of ACS14, and of its deacetylated metabolite (ACS21), the preliminary pharmacokinetics, and its in vivo metabolism, with the H 2 S plasma levels after intravenous administration in the rat. ACS14 maintains the thromboxane-suppressing...
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