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In the present study, we investigated whether β-hydroxyisovalerylshikonin (β-HIVS) affects the production of proinflammatory mediators such as nitric oxide (NO) and prostaglandin E 2 (PGE 2 ) in BV2 microglial cells. Our data showed that β-HIVS inhibited secretion of NO and PGE 2 and downregulated expression of their main regulatory genes, inducible NO synthesis (iNOS) and...
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