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In silico models are often constructed to aid in the understanding of disease and the production of relevant intervention strategies. Several existing models study the acute inflammatory response, which is of importance in multiple organ dysfunction syndrome and sepsis, both of which have high mortality rates. However, no current model of inflammation considers the unique secretory dynamics of cortisol...
The hypothalamus-pituitary-adrenal is the body 's main stress management system, which responds to any threat to homeostasis or internal environmental balance of the body by controlling the body's cortisol level. Dysregulation of the HPA axis is involved in numerous stress-related diseases including post-traumatic stress disorder and chronic fatigue syndrome. We present a new structured model that...
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