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Lipids stored in skeletal muscle cells are known as intramyocellular lipid (IMCL). Disorders involving IMCL and its causative factor, circulatory free fatty acids (FFAs), induce a toxic state and ultimately result in insulin resistance (IR) in muscle tissue. On the other hand, intramuscular triglyceride (IMTG), the most abundant component of IMCL and an essential energy source for active skeletal...
The fraction of free fatty acids (FFA) is present in skeletal muscles. However, there is almost no data regarding regulation in the content of this intramuscular lipid pool. We took advantage of the isolated muscle preparation to examine whether: a) increasing exogenous concentration of FFA (500µM or 700µM, 30min) b) insulin (10.00 I.U./L, 30min), c) adrenalin (4.4 nM, 30min), or d) contractions (200ms,...
Krawczuk I. and Górski J.: The significance of plasma triacylglycerols in metabolism of free fatty acids and triacylgrylcerols in rat skeletal muscles. Acta Physiol. Pol., The continuous uptake of plasma triacyl- gylcerols has been shown to be necessary to maintain the stable resting concentration of free fatty acids and triacylglycerols only in a muscle composed of fast - twitch oxidative gylcolytic...
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