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Many studies have showed that peroxynitrite-mediated injury on fibrinogen has some relations with Thrombotic diseases. However there are few reports about structural changes of nitrified fibrinogen when metallic ions exist in this reaction. In this study, we use methods of FTIR-ATR spectra and 3D Fluorescence spectra to study the structural changes on fibrinogen after nitration and oxidation damages...
Malignant gliomas are associated with poor prognosis. Photodynamic therapy (PDT), relying on light-activated toxicity of a photosensitizer, has been investigated as a means for improving patient survival. This review presents a summary of clinical results obtained with PDT using different photosensitizers for treating brain malignancies. Particular emphasis is on the use of 5-aminolevulinic acid (ALA)...
We demonstrate the advantage of combining high-resolution Fourier domain optical coherence tomography (OCT) with wide-field time-gated fluorescence lifetime imaging microscopy (FLIM) for a comprehensive morphological and biochemical characterization of atherosclerotic vulnerable plaques (VP).
The binding of efonidipine to bovine serum albumin (BSA) was investigated by fluorescence spectroscopy and circular dichroism (CD) technique. The quenching mechanism of fluorescence BSA by efonidipine showed that efonidipine quenched the fluorescence of tryptophan residue mainly through the collision mode. The thermodynamic parameters DeltaH0 and DeltaS0 were calculated to be 75.95 kJldrmo-1 and 342...
We demonstrate the combined optical coherence tomography (OCT) and fluorescence spectroscopy (FS) system with the aid of double clad fiber (DCF) devices. The combination of the DCF coupler and DCF lens make different optical systems compact all-fiber single unit. Based on the all-fiber OCT-FS system, the simultaneous measurements of structual information and biochemical information of a plant tissue...
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