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The differential diagnosis of widespread pain in older adults is broad, with fibromyaglia syndrome (FMS) leading the list. While the exact pathogenesis of FMS is not clear, recent studies suggest that abnormal pain processing and central sensitization contribute to the development of chronic muscle pain and tender points. Precise diagnosis of FMS requires a targeted history and physical examination...
Duloxetine (DLX), milnacipran (MLN), and pregabalin (PGB) are the only drugs licensed by the US Food and Drug Administration (FDA) for fibromyalgia syndrome (FMS). Evidence on the comparative benefits and harms is still accruing. The authors searched MEDLINE, SCOPUS, Cochrane Central Register of Controlled Trials, and sought unpublished data from the databases of FDA, US National Institutes for Health,...
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