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Familial adenomatous polyposis (FAP) is mainly caused by germline mutations in the adenomatous polyposis coli (APC) gene. This study aimed to detect pathogenic variants in five Chinese FAP families and review all previously reported pathogenic variants of APC gene in Chinese population.Five non-consanguineous FAP families and 100 unrelated ethnicity-matched controls were included in the study. Sanger...
Infantile and childhood hepatoblastoma (HB) occurs more frequently in children with hereditary predisposition to familial adenomatous polyposis (FAP) than in the general population. The occurrence of HB in two infant siblings is reported. The sister died of the disease. The brother survived the HB and was later diagnosed with familial adenomatous polyposis and advanced rectal cancer. He was found...
Our previous studies with the mouse model of familial adenomatous polyposis (FAP), C57BL/6J-APC Min /+ or Min mouse, demonstrated the optimal dose for adenoma reduction with R-flurbiprofen was 10 mg/kg/day as an undivided dose. Divided doses exhibited no increased efficaciousness . This study examines 10 mg/kg R-flurbiprofen daily (qd) on survival as well as a second daily (q.o.d...
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