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NO is crucial for endothelial function and vascular health. Plasma nitrite (NO 2− ) is the main oxidation product of NO and has been shown to reflect changes in eNOS activity. We hypothesized that plasma NO 2− response to physical exercise stress along with physiological endothelial function would be reduced with increasing severity of vascular disease. Subject groups were:...
Nitric oxide (NO) bioavailability is important in vascular health, but unsuitable as a clinical measure due to biological oxidation. Total nitrogen oxides (NO x ) are stable but background nitrate levels make it difficult to detect disease-based variation. We investigated the clinical discriminatory value of NO x as it relates to exercise capability (VO 2peak ) and brachial...
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