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Aging is associated with declines in executive function. We examined how executive functional brain systems are influenced by clinically silent Alzheimer's disease (AD) pathology and cerebral white-matter hyperintensities (WMHs). Twenty-nine younger adults and 34 cognitively normal older adults completed a working memory paradigm while functional magnetic resonance imaging was performed. Older adults...
Near-infrared spectroscopy (NIRS) is a promising neuroimaging tool for the study of human cognition. Here, we show that event-related NIRS is able to detect age-related differences in the neural processing in a simple visual Go/NoGo task using a relatively fast (stimulus onset asynchrony approx. 1.4s) event-related design together with a model-based analysis approach. Subjects were healthy young (<30years)...
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