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SNP genotyping device is an essential tool in the upcoming era of personal genome, personalized medicine. Human genome has more than 10 million SNPs while conventional SNP genotyping device can only hold 1 million SNPs. Thus intelligent SNP contents selection is required to maximize the value of SNP genotyping device. Here, we developed a new selection algorithm and applied this method to design genotyping...
In recent years there has been a rapid growth in patient monitoring and medical data analysis using a number of computer-aided systems based on expert systems, fuzzy logic and many other intelligent techniques. Fuzzy logic-based expert systems have shown potential to improve clinician performance by imitating human thought processes in complex circumstances and accurately executing repetitive tasks...
This paper addresses mutational events that give rise to differing response to drugs focusing on Rac1, a protein that has been recognized as a target for drug design for cardiovascular disease due its regulatory role of angiogenesis. Rac1 has been considered with reference to Single Nucleotide Polymorphism (SNP), which has become of great value for personalized medicine. We have considered four variation...
Experimental methods such as high-throughput screening have widely used for discovery of the new drug targets. We employed an idea that disease-related proteins tend to be work as an important factor for architecture of the disease network in this study. To determine new drug target proteins, we proposed a new methodology that analyzes the human disease network by using informational technology. We...
Many different methods exist for pattern detection in gene expression data. In contrast to classical methods, biclustering has the ability to cluster a group of genes together with a group of conditions (replicates, set of patients or drug compounds). However, since the problem is NP-complex, most algorithms use heuristic search functions and therefore might converge towards local maxima. By using...
An objective and uncontaminated method for the assessment of capacity to transduce information has been developed, using a portable computer, and is totally self-contained for data acquisition, analysis and reporting. The evaluations conducted are suitable for the literate and illiterate alike, and are brief and nonthreatening. Once an individual has established a baseline grading, the person acts...
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