The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
Each HIV-1 patient has a diverse population of virus strains in his/her body as the virus quickly replicates and mutates, requiring a combination drug therapy optimized to the patient's unique viral population. Towards this goal, prediction systems have been developed to deduce the susceptibility of a given HIV genotype to a single drug. Many are rule-based systems or rely on hand-crafted features...
In this paper, we analyse the behaviour of osteosarcoma cancer cells which are either exposed to the anticancer agent Topotecan or not exposed to any external agent. For the analyses of cell lineage data encoded from time lapse microscopy, we choose data mining tools that generate interpretable models of the data, and we address their statistical significance. We consider the mortality of unexposed...
Genetic algorithm (GA) applied to feature selection and model optimization improved the performance of robust mathematical models such as Bayesian-regularized neural networks (BRANNs) and support vector machines (SVMs) on different drug design datasets. The selection of optimum input variables and the adjustment of network weights and biases to optimum values to yield generalizable predictors were...
An intelligent prediction system has been developed to discriminate drug-like and non drug-like molecules pattern. The system is constructed by using the application of advanced version of standard multilayer perceptron (MLP) neural network called Hybrid Multilayer Perceptron (HMLP) neural network and trained using Modified Recursive Prediction Error (MRPE) training algorithm. In this work, a well...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.