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Rationale. Drug discrimination studies with clozapine have shown that such assays are of value in analysing the actions of novel antipsychotic agents in vivo. Objectives. To evaluate the role of specific receptors in the discriminative stimulus properties of the novel atypical antipsychotic quetiapine. Methods. Rats were trained to discriminate quetiapine at 10mg/kg and tested with a range of ligands,...
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