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Poly(glycerol sebacate) (PGS) has become one of the most promising new tissue engineering scaffold materials-of-construction. We hypothesized that the lipase inhibitor Orlistat might be suitable for inhibiting lipase-mediated PGS degradation. Here we investigated whether Orlistat can: (1) be physically transported into PGS using 70% (v/v) ethanol in water as a carrier, (2) be stably entrapped within...
Nano-indentation studies using atomic force microscopy (AFM) were introduced to investigate the effects of hydrolysis degradation on mechanical properties of polyglactin 910 monofilament sutures. The polyglactin 910 sutures were immersed in phosphate buffered saline (PBS) solution of pH 5, 7.4, 10 without enzyme and pH 7.4 with esterase enzyme. After that, the samples were incubated at 37°C under...
Nanocomposites of poly(lactic acid) (PLA) reinforced with cellulose whiskers highly dispersed with poly(ethylene glycol) (PEG) were prepared for the first time. The composites obtained by solvent casting methods from N, N-Dimethylacetamide (DMAc) were characterized by mechanical testing, fourier transform infrared spectroscopy (FT-IR), water absorption and biodegrade in simulated body fluid (SBF)...
Our research focused on the Characteristics of HPAM degradation, using 11 hydrolyzed polyacrylamide degrading bacteria strains that were gained from Daqing field. In this study, we demonstrated that the degradation capability of the mixed strains was stronger than each single one. In addition, Infrared spectrum analysis and Gas Chromatography analysis on HPAM degradation products showed that, parts...
We are testing degradation rates of calcium sulfate/polymer composites meant for use as bone graft substitutes. The goal is to demonstrate the potential of composite degradable and biocompatible materials that will resorb slower than pure calcium sulfate. We will determine which composites give us degradation profiles that are appropriate for different types of bone regeneration.
A novel nano-hydroxyapatite/multi-(amino acid) copolymer (n-HA/MACP) composite was prepared by in situ polymerization and characterized by FT-IR XRD, mechanical measurement, in vitro degradation experiments and cell growth behavior. FT-IR and XRD results showed that the composite was composed of n-HA and an amide linkage structure and hydrogen bond was formed between n-HA and the copolymer. The composite...
We present a polymer microvalve that allows the detection of biopolymer degradation without the need of external energy. The valve is based on a polymer container filled with a colored marker solution and closed by a thin lid. This structure is covered by a film of poly(L-lactide) and degradation of the biopolymer triggers the release of the color which is detected visually. The autonomous valve has...
In the present study, poly (D, L-lactic acid) (PDLLA) modified genipin-cross-linked chitosan/gelatin scaffolds loaded icariin were prepared. The scaffolds with genipin cross-linking were fabricated with lyophilization, and then were immersed into the 2.5%, 5.0%, and 7.5% PDLLA-dichloromethane solutions. Thus the PDLLA modified genipin-cross-linked scaffolds were obtained after evaporating the solvent...
The present work examines porous scaffolds preparation methods by combining salt leaching, gas forming, solvent evaporation and phase separation techniques. The scaffolds are intended for bone tissue regeneration. It aims to combine the biodegradability of poly (epsiv-caprolactone) (PCL) with the osteoconductive properties of hydroxylapatite (HA) in order to create a composite which acts as a temporary...
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