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Dynamic programming in bioinformatics is a memory based data structure for saving computational time with one-time storage of each problem solution. Algorithm and Scoring parameters are used to evaluate Brainstem Glioma patients DNA Sequence and comparing each other. 1. Local comparison a. Ignoring disparate sequences outside similar sequences b. locally arrange similar sequence. 2. Global comparison...
Knowledge extraction from genomic data is important activity for the biologist. In order to extract the underlying biological knowledge, we based on the generic framework of Knowledge extraction from data. In this paper, we transformed DNA sequences into texts, the texts are indexed by TF-IDF and n-grams approach. Secondly, we grouped the similar DNA sequences by clustering; we applied bio-inspired...
DNA-binding proteins perform their functions through specific or non-specific sequence recognition. Although many sequence-based approaches have been proposed to identify DNA-binding residues on proteins or protein-binding sites on DNA sequences with satisfied performance, it remains a challenging task to unveil the exact mechanism of protein-DNA interactions without crystal complex structures. Without...
This paper firstly gives a brief overview of information embedding in deoxyribonucleic acid (DNA) sequences and its applications. DNA data embedding can be considered as a particular case of communications with or without side information, depending on the use of coding or noncoding DNA sequences, respectively. Although several DNA data embedding methods have been proposed over the last decade, it...
Processing of biomolecular sequences using communication theory techniques provides powerful approaches for solving highly relevant problems in bioinformatics by properly mapping character strings into numerical sequences. We provide an optimized procedure for predicting protein-coding regions in DNA sequences based on the period-3 property of coding region. We present a digital correlating and filtering...
Classification is a major task in the gene sequence analysis. Based on the general principle of artificial immune system, this paper first constructed a classifier which inducted antibody-antigen identification, immune colonel reproduction, hypermutation, affinity mature and the network suppression, by simulating how the antigens stimulate the immune network and how the immune network responds. Then,...
In 1957 Crick hypothesized that the genetic code was a comma free code. This property would imply the existence of a universal coding frame and make the set of coding sequences a locally testable language. As the link between nucleotides and amino acids became better understood, it appeared clearly that the genetic code was not comma free. Crick then adopted a radically different hypothesis: the "frozen...
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