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DNA sequences are often found to be composed of locally homogeneous segments that are functionally important. Most sequence comparison methods do not consider such a compositional property. We introduce a new method that takes this issue into consideration. With our method, the information of a DNA sequence is first transformed into a multi-order transition matrix (MTM); the resulting matrices are...
The statistical structure of DNA-sequences is of a great interest to molecular biology, genetics and theory of evolution. One of the approaches is sequence modeling using Markov processes of different orders, and further statistical estimation of their parameters. This approach is evolved in the paper and the test for serial independence, suggested by Ryabko, Astola (Stat.Methodology, 2006), is used...
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