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Acute myocardial infarction (AMI) diagnosis in type II diabetes (DM2) patients is difficult and ECG findings are often non-diagnostic or inconclusive. We developed computer algorithms to process standard 12-lead ECG input data for quantitative 3-dimensional (3D) analysis (my3KGTM), and hypothesized that use of the my3KGTM's array of over 100 3D-based AMI diagnostic markers may improve diagnostic accuracy...
Cardiovascular autonomic neuropathy (CAN) is one of the important causes of mortality among diabetes patients. Statistics shows that more than 22% of people with type 2 diabetes mellitus suffer from CAN and which in turn leads to cardiovascular disease (heart attack, stroke). Therefore early detection of CAN could reduce the mortality. Traditional method for detection of CAN uses Ewing's algorithm...
Diabetes mellitus is a chronic metabolic disease that displays hyperglycaemia and that is strongly linked to micro and macro-vascular complications and neuropathic ones. The World Health Organization (WHO) states that there are around 171 million diabetic patients in the world, it's also estimated that this amount will double by 2030. We have performed a preliminary study on 35 volunteers, including...
Cardiovascular Autonomic Neuropath (CAN) is a poorly understood chronic complication of Diabetes Mellitus (DM). A single instrument to evaluate CAN is not available yet, because of the complex balance between both sympathetic and parasympathetic drives. Heart Rate Recovery (HRR) is a promising parameter for clinicians to use, which is the difference between the maximal heart rate achieved at the end...
Patients with idopathic dilated cardimyopathy (IDC) and reduced left ventricular function have a limited prognosis. Aim of this study was the evaluation of parameters of cardiac magnetic resonance imaging (CMRI) and ECG for prognosis. 149 patients with IDC were studied by CMRI for hemodynamic and late enhancement (LE) analysis and followed for a mean of 986 plusmn 588 days. QRS and QTc intervals were...
Blood pressure dynamicity during tilt table measurement is discussed. We analyzed ECG and BP parameters from 14 normotensive young healthy volunteers, 15 old healthy volunteers, and two groups of hypertensive patients - 20 non-medicated hypertensive subjects with no other known complications and 21 hypertensive non-medicated subjects with confirmed obesity (according to waist circumference), hyperlipidemia...
The heart rate variability (HRV) is effected by the presence of diabetes mellitus (DM). Specifically, the power spectral density (PSD) of the HRV is perturbed in specific frequency ranges. This study presents the algorithm employed to extract changes in the PSD due to the onset of DM. In particular, streptozotocin (STZ) is administered to test animals in order to impair the insulin producing, pancreatic...
This paper presents results of blood pressure dynamicity analysis aimed at vessel stiffness detection and subsequent cardiac risk stratification. We analyzed ECG and BP parameters from 12 normotensive young healthy volunteers, 10 old healthy volunteers, and two groups of hypertensive patients-12 young non-medicated hypertensive subjects with no other known complications and 16 hypertensive non-medicated...
This paper presents results of blood pressure dynamicity analysis aimed at vessel stiffness detection and subsequent cardiac risk stratification. We analyzed ECG and BP parameters from 12 normotensive young healthy volunteers, 10 old healthy volunteers, and two groups of hypertensive patients-12 young non-medicated hypertensive subjects with no other known complications and 16 hypertensive non-medicated...
Analysis of heart rate variability (HRV) has become a popular non invasive tool for assessing the activities of autonomic nervous system. Depressed HRV has been found in several disorders, like diabetes mellitus (DM) and coronary artery disease, characterised by autonomic nervous dysfunction. A new technique, which searches for pattern repeatability in a time series, is proposed specifically for the...
The risk for cardiovascular disease is significantly high in diabetes mellitus. Experimental evidence suggests that oxidative stress plays a dominant role in the pathogenesis of diabetes mellitus. Carvedilol, a non-selective beta-adrenoceptor and selective alpha1-adrenoceptor blocker, also has antioxidant and free radical scavenger properties. In the present study the effect of carvedilol on the antioxidative...
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