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Deep brain stimulation (DBS) is widely used for the treatment of various neurological diseases such as Parkinson's disease and tremors. Owing to the inherent limitations of the imaging modalities, physicians have a difficulty in the diagnosis of the exact response to the brain tissues during stimulation. Recent magnetic resonance (MR)-based electrical impedance tomography (MREIT) enables estimation...
Deep Brain Stimulation (DBS) is a clinically suitable technique for the treatment of the Parkinson's disease. Recently, also other neurological disorders such as Tourette syndrome, obsessive-compulsive disorder, epilepsy are being to be treated with DBS. However, the debate on its therapeutic mechanisms of action is still open. In order to a better understanding of such mechanisms, in this work the...
Deep brain stimulation (DBS) is a clinical tool adopted to treat various neurological disorders, including chronic pain, incontinence and movement disorders. One major limitation of commercial DBS systems is the inability to control the distribution of the electric field around the target region, resulting in the activation of both target and non-target neural clusters. The authors have previously...
This study was conducted to determine if DBS induced electric fields will result in local electroporation of blood vessels. We designed an in-vitro stimulation system using uniform fields and bovine aortic endothelial cells (BAECS) confluent monolayers. The cells were quantified for reversible electroporation (uptake) and irreversible electroporation (cell death) by calcein and propidium iodide, respectively,...
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