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In this paper we demonstrate by simulation, that the spike features apparent in low-impedance deep brain stimulation (DBS) targeting microelectrode recordings (MER) may not reflect the action potentials of individual neurons. Rather, they are more likely to be compound action potentials from a synchronized group of neurons local to the electrode. Initially we simulate the MER by combining the electric...
The goal of this paper is to develop a quantitative understanding about the shape and the volume of tissue activated (VTA) and stimulation sites by deep brain stimulation (DBS) in deep brain area like subthalamic nucleus (STN) to improve neural stimulation. Monopolar current steering approach has been studied in cochlear implants and deep brain stimulation. In this paper, novel bipolar and tripolar...
Deep Brain Stimulation (DBS) is a clinically suitable technique for the treatment of the Parkinson's disease. Recently, also other neurological disorders such as Tourette syndrome, obsessive-compulsive disorder, epilepsy are being to be treated with DBS. However, the debate on its therapeutic mechanisms of action is still open. In order to a better understanding of such mechanisms, in this work the...
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