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A kind of polymeric prodrug of ibuprofen with glucose pendant was prepared through chemo-enzymatic method. The obtained polymeric prodrug was characterized by FT-IR, NMR and GPC. The molecular weight of the polymeric prodrug reached 2.126 × 104. Furthermore, the in vitro release behaviors of ibuprofen (raw drug) and the polymeric prodrug were investigated in pH 7.4 buffer solution at 37°C. It was...
Ebp1 is a member of the PA2G4 family protein and initially isolated as an ErB3 (an epidermal receptor tyrosine kinase) binding protein. Ebp1 inhibits cell growth and repress transcription of E2F-regulated cell cycle genes. Previously, we reported that Ebp1 protein interacted with RNA polymerase subunit PB1 of the influenza virus and disturbed in vitro RNA synthesis by influenza RNA polymerase. Recently...
A facile procedure combining enzymatic resolution with chemical polymerization was developed to prepare optically active polymeric prodrug containing glucose. Polymerizable optically active (R)-1-O-vinyladipoyl-chlorphenesin ((R)-OVAC) was obtained in excellent optically purity (ee>99.9%) and high yield (~50%) in short time, and optically active (S)-N-vinyladipoyl-propranolol ((S)-NVAP) was obtained...
Electrospun nylon-6 nanofibrous membrane with fiber diameters in the range of 50-200 nm were prepared and employed as affinity membrane material for papain adsorption due to their excellent chemical and thermal resistance as well as high wettability. In this work, covalent coupling of chitosan (CS) to activated nylon membrane was performed after the reaction of the nanofibrous nylon membrane with...
Nylon membranes are first hydrolyed with dilute HCl and then treated with chitosan before being used as the affinity carrier. Papain as a ligand has been immobilized on the activated membranes with glutaraldehyde as a crosslinking agent. The factors involving with the activity of immobilized papain, such as concentration of glutaraldehyde, pH, temperature, reaction time, and the amount of added papain...
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