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Nerve agents are tetrahedral organophosphorus compounds (OPs) that were developed in the last century to irreversibly inhibit acetylcholinesterase (AChE) and therefore impede neurological signaling in living organisms. Exposure to OPs leads to a rapid development of symptoms from excessive salivation, nasal congestion and chest pain to convulsion and asphyxiation which if left untreated may lead to...
The extreme toxicity and rapid action of organophosphorus (OP) containing nerve agents and pesticides make them a vital target for the development of antidotes and prophylactics. In this review on page 13280 ff., J. D. Badjić and colleagues explore the realm of abiotic hosts in the sequestration and isolation of these potent toxins. A variety of the molecular hosts that have shown to bind and deactivate...
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