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We investigated the immunosuppressive effects of the dihydroortate dehydrogenase (DHODH) inhibitor compounds ABR-222417 and ABR-224050 from Active Biotech (Sweden). We verified the inhibitory effects of these compounds on the proliferation of CD4 + and CD8 + T-cells in vivo by using superantigen staphylococcus enterotoxin A (SEA)-mediated proliferation test. To evaluate their efficacy,...
Data are scarce concerning the calcineurin inhibitor dose reduction required following introduction of everolimus in maintenance heart transplant recipients to maintain stable renal function. In a 48‐week, multicenter, single‐arm pilot study in heart transplant patients >12 months post‐transplant, everolimus was started at 1.5 mg/day (subsequently adjusted to target C0 5–10 ng/ml). Mycophenolate...
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