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In this work, we present a computational model of a quietly standing human. The model is composed of a system of three rigid links with two joints, one at the ankle and one at the hip. This is consistent with considerable experimental data which indicates that humans keep their knee angle nearly constant when dealing with small perturbations to their posture. An optimal control problem is designed...
Ventricular fibrillation in the human heart results in global myocardial ischaemia. The aim of this study was to examine how ischaemia modulates the stability and period of re-entry in a computational model of human ventricular tissue. 2D tissue sheets were simulated using the monodomain equation with cellular electrophysiology described by the Ten Tusscher 2006 model. We modeled ischaemia by elevating...
Here, we promote the perspective that a computational model can be a rigorous crystallization of a hypothesis for the mechanisms generating observed data. We provide an example of using this approach to discriminate among hypotheses despite uncertainty in parameter values. Humans have been shown to produce non-uniform patterns of force fluctuation when they exert force in different directions with...
In this work we present a new electromechanical cardiac myocyte model tailored to reproduce the electrical and force generating activities of human ventricular myocytes. The model was created by coupling two existing models: the ten Tusscher electrophysiology model and the Rice myofilament mechanics model. The parameters of the new model were adjusted in order to replicate the available experimental...
Recent studies have indicated postmenopausal women receiving hormone replacement therapy (HRT) have more adverse outcomes of peripheral arterial disease after vascular reconstruction, including increased intimal hyperplasia (IH) and restenosis. The major cellular processes contributing to IH pathogenesis are extracellular matrix (ECM) degradation and vascular smooth muscle cell (VSMC) proliferation,...
How the incoming sensory information and the knowledge of body dynamics are combined by the nervous system to control movement execution? One way to investigate this is to design experiments in which movements are perturbed by either an unfamiliar dynamic environment, or by alterations in the available sensory information. Then we may look at the resulting errors patterns, and at whether and how the...
Cardiac arrhythmias are mainly due to failure in the coordination among contraction of cardiac muscle. Among several types of arrhythmias, we focused on ventricular reentrant arrhythmia because it is more dangerous arrhythmia. With the help of detailed biophysical model of human ventricular cell, the role of sodium ion concentration and calcium currents on single and one-dimensional array of cells...
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