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The object of this review is to provide the definitions, frequency, risk factors, pathophysiology, diagnostic considerations, and management recommendations for diabetic ketoacidosis (DKA) in children and adolescents, and to convey current knowledge of the causes of permanent disability or mortality from complications of DKA or its management, particularly the most common complication, cerebral edema...
Diabetic ketoacidosis (DKA) remains the commonest cause of diabetes-related deaths in children and most deaths occur as a result of cerebral oedema. There are now internationally agreed guidelines for the management of DKA, which aim to optimise treatment and to minimise the risk of complications including cerebral oedema. Much of the guidance is consensus rather than evidence based, but knowledge...
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