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To evaluate chosen serum cytokines and their association with osteoarthritis (OA) in the guinea pig.The levels of 18 cytokines were measured in Hartley guinea pig serum at time points ranging from 3 weeks to 18 months of age. These levels were then tested for any correlation with total histology, and a comprehensive evaluation of these statistics was conducted using data previously collected from...
To identify biochemical markers of osteoarthritis (OA) in the guinea pig, we characterized four biomarkers and 17 cytokines for age- and strain-related differences.Two guinea pig strains were examined in this study: (1) the Hartley (OA-prone) and (2) Strain 13 (OA-resistant). Levels of synovial fluid keratan sulfate (KS) and cartilage oligomeric matrix protein (COMP), as well as levels of serum C2C,...
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