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Interaction between long DNA molecules and activated cisplatin is believed to be crucial to anticancer activity. However, the exact structural changes of long DNA molecules induced by cisplatin are still not very clear. In this study, structural changes of long linear double-stranded DNA (dsDNA) and short single-stranded DNA (ssDNA) induced by activated cisplatin have been investigated by atomic force...
The interactions of the several linear DNA fragments and cisplatin at different concentrations and incubation time have been studied by atomic force microscopy. When equal volume of 2mM cisplatin and 5ng/μl 1134bp DNA fragment were incubated for 30min, 1h, 2h and 3h, the observed DNA were gradually changed from the extended chains to the bending structures, the worm-like structures and flat particles...
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